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Stern JH, Smith GI, Chen S, Unger RH, Klein S, Scherer PE

If we dont pair them with appropriate lifestyle changes, they can have negative consequences such as muscle mass loss, nutrient depletion, hair loss and rebound weight gain once discontinued, especially considering the lower RMR from weight and potentially muscle loss

GLP-1s only work while youre actively taking them

These platforms surpass monotherapies by providing synergistic action, spatial-temporal precision, and sustained therapeutic pressure, essential for combating resistance and relapse

However, based on its pharmacological profile and the cautions listed in the UK SmPCs for related approved medicines (including semaglutide and tirzepatide), certain groups are likely to require particular caution or may be excluded from future prescribing