American Journal of Translational Research, 10 (11), 3322-3329
Due to increasing health and longevity consciousness among consumers, functional foods and nutraceutical products with glutathione content are growing in demand
Peripheral whole blood was collected in the perioperative setting via a venous catheter immediately before surgery using K 2 -EDTA-coated tubes (BD Biosciences, 367899)
Antioxidant GSH is the most powerful antioxidant occurring naturally in your body
Mechanistically, GLPs exert renoprotective effects by suppressing the PI3K/Akt/mTOR signaling cascade, promoting autophagicevidenced by increased Beclin-1 expression and LC3-II/LC3-I ratio, along with decreased p62 accumulationwhile simultaneously attenuating apoptotic activity (reducing caspase-3 and caspase-9 levels) and dampening pro-inflammatory responses (lowering IL-6, IL-1, and TNF-)