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There are many reasons your stool could contain blood, and while most causes are fairly harmless, blood can sometimes indicate a more serious condition

However, the metabolic signature associated with good and poor response to metformin therapy is crucial to adjust the treatment that best suit the patient

Larger, longer trials are clearly needed to confirm these effects and to watch for late side effects

*Correspondence: Alessandro Armuzzi, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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