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The researchers found that the EDR peptide binds specifically to the promoter regions of several genes critically involved in AD pathogenesis, including CASP3 (caspase-3, involved in apoptosis), NES (nestin, a neurogenesis marker), GAP43 (growth associated protein 43, involved in neuroplasticity), and APOE (apolipoprotein E)

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Multiple psychiatric studies over the past decades established that acetylcholine (ACh) and monoamines (MAs) including norepinephrine, dopamine, histamine, and serotonin are involved in a wide range of psychiatric disorders, including those marked by pathological impulsivity (4244)