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For a long time, lactate in the adult brain has not been considered more than a mere by-product of anaerobic metabolism

M., Byun, J., Roh, S

Sutherland A, Meldon C, Harrison T, Miller M

The folate is in your bloodstream, but blocked from entering your brain

But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own