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The evolving therapeutic landscape demands we weigh metformins benefits against newer agents that offer more than glucose control alone

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Butyrate was shown to decrease steatohepatitis in a high-fat diet-induced steatohepatitis mouse model by repairing high-fat diet-induced damage to the intestinal mucosa, upregulating zonulin, and lowering endotoxin levels (Tong et al., 2016)

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