glp 1 cause dry mouth GLP-1 Receptor Signaling and Oral Dysfunction: A Narrative Review on the Mechanistic Basis of Semaglutide-Related Oral Adverse Effects Ozempic Teeth: Protect Your Smile

[DOI] [PMC free article] [PubMed] [Google Scholar] 749.Farber C.R., Bennett B.J., Orozco L., Zou W., Lira A., Kostem E., Kang H.M., Furlotte N., Berberyan A., Ghazalpour A., et al

462 Inhibition of the NF-B signaling pathway leads to the decreased production of inflammatory mediators, including adhesion molecules and chemokines, which are crucial for the recruitment of immune cells to sites of inflammation

For example, in a semaglutide clinical trial in teens, gastrointestinal adverse events were reported in 62% of the group taking semaglutide, compared to 42% in the placebo group

There is also evidence that GLP-1RA has positive effect on metabolic syndrome and abdominal obesity

This variation in pharmacokinetics across GLP-1 is critical when considering each drugs suitability for pregnancy, as it directly impacts blood glucose control, convenience, and potential adherence in GDM management