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Thirty-three male subjects were randomly assigned to either a placebo (P), creatine ( C), or creatine plus -alanine (CA) group

At lower doses, appetite suppression still may happen, but its often milder

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The 4 amino acids with either a strongly or weakly acidic chain, pI is the average of the two lowest pKa values The 13 amino acids with a neutral side chain, pI is the average of pKa1 and pKa2 The 3 amino acids with a basic side chain, pI is the average of the two highest pKa values