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The rubber stopper is designed to be punctured by a sterile needle for medication withdrawal, not removed entirely

Hydroxocobalamin 1mg/ml Solution for Injection Patient Information Leaflet (PIL 100455)

Other causes include gastrectomy, Crohn's disease, celiac disease, bariatric surgery, and chronic use of certain medications, such as proton pump inhibitors (PPIs) and metformin

Human safety data is limited BPC-157 has not been through large controlled trials, so its long-term safety profile is not established the way it is for an approved drug