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The danger of dose splitting Sometimes, a healthcare professional or an acquaintance might suggest you take a pen with a higher dose and split the dose per week by counting the number of clicks for accurate dosing

Meanwhile, GLP-1 receptor activation in the hypothalamus, specifically in the arcuate nucleus and paraventricular nucleus, directly suppresses hunger signals by activating satiety-promoting POMC/CART neurons while inhibiting hunger-promoting NPY/AgRP neurons

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Liver health also plays a critical role