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Insulin receptors (IRs) and downstream signaling mediators are abundant in brain regions involved in seizure initiation and modulation, including the hippocampus, cortex, amygdala, and thalamus [Table 1]

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One of the most promising drug classes in recent years is GLP-1 receptor agonists, including semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro).These medications have revolutionized weight loss and diabetes management, with additional potential benefits in reducing risks for conditions like sleep apnea, cardiovascular disease, and even alcohol dependence

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