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doi: 10.1146/annurev.biochem.76.052305.091720 60 AndersonCABoucherGLeesCWFrankeAD'AmatoMTaylorKDet al

Discussion Acetaminophen overdose is the most common cause of drug-induced liver injury in the United States 2

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Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors