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At doses of 400 mg/day in adjunctive epilepsy therapy trials, persistent reductions in serum bicarbonate 5 mEq/L reduction from baseline) occurred in 3% of topiramate-treated patients vs

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CD4 + CD25 + Foxp3 + Tregs cell dysfunction is common in autoimmune diseases (199), and it may be converted into pathogenic Th17 cells after repeated amplification (200)