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Despite the absence of experimental studies in pregnant women, a 3-week experiment among 20 pregnant rats found that the aqueous extract of bitter leaf has an abortifacient effect, and is associated with reduced serum progesterone levels

In some cases, long-term maintenance doses of progesterone might be required to prevent the return of hypersensitivity

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The results showed that the proportion of senescence-associated markers positive cells was enhanced in keloid fibroblasts (59.5%) versus normal skin fibroblasts (36.5%) (Fig