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Interestingly, USP1 displays a strong tissue-specific expression

Appl Microbiol Biotechnol 94:13131319 Hara KY, Aoki N, Kobayshi J, Kiriyama K, Nishida K, Araki M, Kondo A (2015) Improvement of oxidized glutathione fermentation by thiol redox metabolism engineering in Saccharomyces cerevisiae

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The trade-off: chronic growth hormone elevation suppresses endogenous pulsatility through negative feedback at the hypothalamus, reducing the amplitude of natural nocturnal pulses

[xiv] Lee S, Lee DY