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Ultimately, GLP-1RAs enhance insulin excretion, leading to the inhibition of glucagon production by pancreatic -cells when blood sugar levels are high as well as a decrease of pancreatic -cell apoptosis and an increase in their proliferation

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These mechanisms include: slowing gastric emptying increasing satiety signals in the brain reducing appetite lowering overall calorie intake Because food remains in the stomach longer, patients tend to feel full sooner and remain satisfied for longer periods after meals

Another retrospective study found better survival in UIP-type IPF with positive antinuclear antibody, possibly due to higher TOLLIP-TT prevalence (141)