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Its a two-way street in IBD, with the gut microbiome changes potentially causing high homocysteine, but then high homocysteine will increase the inflammation in the gut.[ref] Gastrointestinal production of homocysteine: Gut microbes that produce folate: The amount of folate produced by the gut microbiome is on a similar scale to what we get from food, so it is a significant source of folate for most people

BH4 is not only a crucial enzyme cofactor but also a potent radical scavenger

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Most of the side effects of semaglutide are gastro-intestinal related due to how it works in your body

In general, excess B12 is flushed out by your body and is unlikely to cause harm