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Abbreviations AHA: American Heart Association ASCVD: Atherosclerotic cardiovascular disease CI: Confidence interval CMA: A conventional meta-analysis CVD: Cardiovascular disease EASD: European Association for the Study of Diabetes ESC: European Society of Cardiology FPG: Fasting plasma glucose GLP-1RA: Glucagon-like peptide-1 receptor agonists HbA1c: Hemoglobin A1c LVEF: Left ventricular ejection fraction MACE: Major adverse cardiovascular events MD: Mean difference PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses QALY: Quality-adjusted life year RCT: Randomized controlled trial RIS: Required information size RoB2: Risk of bias tool for randomized trials RR: Risk ratio SD: Standard deviation SE: Standard error SGTL-2i: Sodium-glucose co-transporter-2 inhibitors T2DM: Type 2 diabetes mellitus TAU: Treatment as usual TSA: Trial sequential analysis UTI: Urinary tract infection References Low Wang CC, Hess CN, Hiatt WR, Goldfine AB

Management of hyperglycaemia in type 2 diabetes, 2018

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The injections are given under the skin of the abdomen, thigh, or upper arm

Tablets with L-carnitine for adults, physically active people