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PMID: 40685589 | doi:10.1002/oby.24360 Misra S et al

By activating GLP-1 receptors throughout the body, it produces several effects relevant to weight loss: Reduced appetite and food intake by acting on hunger centres in the brain Slowed gastric emptying food leaves the stomach more slowly, increasing feelings of fullness Improved insulin secretion in response to food, and reduced glucagon release relevant particularly for patients with type 2 diabetes Mounjaro (tirzepatide) dual GIP and GLP-1 receptor agonist Mounjaro activates both the GLP-1 receptor and the GIP (glucose-dependent insulinotropic polypeptide) receptor