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Dietschmann, A

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Approval (2017) Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation (May 17, 2025) Semaglutide (February 11, 2024) Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial (March 23, 2021) Weight Regain And Cardiometabolic Effects After Withdrawal Of Semaglutide: The Step 1 Trial Extension (May 19, 2022)

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Patients can experience these symptoms which subside after a few weeks: Nausea Vomiting Diarrhea Constipation Upset stomach Tiredness Dizziness Rare, severe side effects of semaglutide injections include: Kidney problems Pancreatitis Gallbladder problems Blurred vision Increased heartbeat Low blood sugar Depression Suicidal thoughts Sudden sweating Shaking Tingling in the hands and feet Shortness of breath Semaglutide has a black box (strictest) FDA warning because it can potentially cause thyroid C-cell tumors