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No obstante, su implementacin no est exenta de retos, visto que en la prctica clnica cotidiana ya se observan efectos secundarios previsibles, como la prdida de masa muscular cuando no se acompaa de una estrategia nutricional adecuada, el uso indiscriminado en pacientes sin indicacin clara y barreras significativas de acceso derivadas de su costo

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