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Recent studies have shown that tumor-derived lactate enhances H3K18 lactylation, inhibiting RAR gene transcription in macrophages and thereby increasing interleukin-6 (IL-6) levels within the TME, activating the TRAF6-IL-6-STAT3 signaling pathway, which promotes tumor-promoting functions in macrophages (113)

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Key players in the biosimilars market include Sandoz Group AG (Switzerland), Pfizer Inc