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BCAA includes Leu, iLe, and valine, and all three amino acids participate in the citric acid cycle by producing acyl-CoA derivatives via branched-chain amino acid transferase (BCAT), branched-chain -keto acid dehydrogenase (BCKDH), which in a subsequent series of reactions produce acetyl-CoA

However, rhosin treatment inhibited the increase in the OARSI score observed in DMM mice (Fig