This damage disrupts the normal flow of electrical signals between the brain and body, leading to a wide range of symptoms, including fatigue, mobility problems, vision issues, numbness, and cognitive changes
10.1007/s00277-013-1947-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 84.Kerman IA, Buck BJ, Evans SJ, Akil H, Watson SJ
What the Evidence Shows and What It Does Not MedicalDaily Evidence Check Data source: Multiple peer-reviewed studies published 2025-2026, including British Journal of Pharmacology, Nature Reviews Endocrinology, and body composition literature on STEP and SURMOUNT trial data Key finding: Up to 40% of weight lost on high-efficacy GLP-1 drugs is lean body mass
These are consistent predictors of GLP-1 GI side effects across trials
This particular study focused on Ozempic