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Central administration of GLP-1 (736) amide inhibits food and water intake in rats Am J Physiol 1996 271 : ( Regulatory Integrative Comp Physiol 40) R848R856

This mechanism effectively instructs the liver to burn its fat stores for energy, leading to the profound reductions in hepatic steatosis observed in clinical trials

GLP-1 medications stimulate insulin production, reduce glucagon, slow digestion and decrease feelings of hunger all of which contribute to weight loss

In eight CVOTs history of heart failure was reported at baseline and it ranged from 9% to 24% with no significant difference between patients receivng GLP-1 receptor agonist and patients receiving placebo