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The postulated mechanism by which metformin acts as a weight-reducing agent is reducing food intake and increasing insulin sensitivity through tissue-specific AMPK action

From a broader standpoint, starting with the 2 mg dose also set the stage for understanding long-term tolerability

It feels a bit like running a marathon, with the finish line still on the horizon, but every pound lost is like a little victory

Important safety considerations include a boxed warning for medullary thyroid carcinoma risk (contraindicated in patients with MEN2 or family history of MTC), pancreatitis risk, gallbladder disease, and potential for dehydration

Clinicians should inquire about baseline activity levels, including strength training