tirzepatide for kidney disease Not currently a therapy. But this exploratory finding is worth watching closely. 🫘 #ObesityMedicine #Tirzepatide #Type2Diabetes #KidneyHealth #ChronicKidneyDisease #GLP1 #GIP #CardiometabolicHealth #Nephrology #MetabolicHealth #CKD #T2DM New kidney drugs emerge in

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These changes result from the direct effect of GLP-1RAs on proinflammatory cytokines production in monocytes/macrophages as it blocks NF-B, and lowers the formation of pro-inflammatory M1 macrophages

However, one study reported that fentanyl causes an increase in production of reactive oxygen species in freshly isolated peripheral blood lymphocytes 118 , which arguably may involve a reduction in cellular reduced thiol levels

GLP-1 receptor agonists have shown consistent benefit in PCOS: a 2022 meta-analysis in Human Reproduction Update (N=10 trials, 484 women) found that GLP-1 agonist therapy reduced fasting insulin by 1.98 mIU/L, total testosterone by 0.19 nmol/L, and improved menstrual regularity in 55% of participants [10]

Any underlying medical issues would need to be treated