tirzepatide vs semaglutide cardiovascular A trial emulation in Nature Medicine shows that treatment with and showed similar levels of benefit on outcomes in people at elevated cardiovascular risk with obesity and diabetes. Link Tirzepatide Linked to Better CV

In the context of the so-called microbiotagutbrain (MGB) axis, it is shown to have a strong influence on host neuromodulation and endocrine functions (i.e., controlling the synthesis of neurotransmitters like serotonin or mediating the activation of the hypothalamicpituitaryadrenal axis), as well as in modulation of host immune responses, critically regulating intestinal, systemic and brain inflammation (neuroinflammation)

Combined with strong lifestyle capacity, you have reasonable chance at maintaining significant portion of loss off medication

Thirty minutes of brisk walking five days a week provides substantial health benefits with almost zero injury risk Swimming or water aerobics excellent for patients with joint concerns, offering full-body conditioning with minimal impact Cycling stationary or outdoor, cycling is easy to scale in intensity and gentle on the knees Elliptical or rowing machine both provide effective cardio without the pounding of running Timing around meals and injections There is no strict clinical rule about when to exercise relative to your GLP-1 injection

It is not currently FDA approved

On the other hand, glutamate causes higher sensitization of FM pain [17]