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(2017) 6:e1320011

Laboratory studies support this notion: in vitro cultured microglial cells, when exposed to FeCl2, underwent activated morphological changes [188]

Sulfhydryl oxidase 1, QSOX1

They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)