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Description

Adsorptive-mediated transport at the BBB has also been exploited to target nanocarrier systems by using cationic lipids and cell penetrating peptides to increase binding and internalization at the brain capillary endothelium [29, 30], which has a highly negative surface charge [31]

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Ohtsuki M, Okubo Y, Komine M, Imafuku S, Day RM, Chen P, Petric R, Maroli A, Nemoto O (2017) Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: efficacy, safety and tolerability results from a phase 2b randomized controlled trial

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