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95% CI, 0.274 to 0.123

In humans, the distribution volume of valproic acid is roughly 0.14 L/kg, thus showing valproic acid is predominantly limited to bloodstream and ECFs (extracellular fluids), mostly due to ionization at normal pH and with a lot of Valproic acids linked to serum proteins

[1] Topiramate Topiramate is an oral antiepileptic drug (AED) used for partial-onset, generalized primary tonic-clonic seizures, and as an adjunct therapy in Lennox-Gastaut syndrome

Impaired BBB integrity, such as the loss or degeneration of pericytes, disturbs regional CBF, disrupting the delicate balance required for optimal neural function [4,5,6]

(PubMed) Curhan GC, Willett WC, Speizer FE, Stampfer MJ