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The pharmacology is well described in the peer-reviewed literature, but clinical effect sizes vary by indication, dosing, individual factors, and adherence, which is a large part of why frequency cannot be generalized

Because cytochrome P450 reductase (CYPOR) is highly expressed in HepG2 cells and in primary hepatocytes (Schulz et al

If the benefit disappears within days, it was tuning the function of circuits that were already intact, which makes it a nootropic

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The data were presented as the fold increase of the target gene expression, normalized to the housekeeping gene beta-actin, compared to unstimulated conditions