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Previous studies have demonstrated that the effect of GLP-1 involve both GLP-1R-dependent and-independent pathways 53,54

Daily GIP injections led to a decrease in the adipose tissue gene expression levels of pro-inflammatory cytokines, such as Il-1 beta, Il-6, TNF-alpha in wild-type mice, 60 while blood levels of adiponectin, an anti-inflammatory and insulin-sensitizing adipokine, are enhanced

Common titration schedules begin at 0.25 mg weekly and progress through 0.5 mg, 0.75 mg, and 1 mg doses

Allulose, a monosaccharide sweetener, does not directly activate these receptors but may indirectly influence GLP-1 release through glucose-sensing mechanisms

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