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It is not intended as a standalone therapeutic dose for severe B12 deficiency, which would require separate supplementation at different intervals and doses under veterinary guidance

Reduce the dose and increase slowly

There are some people, however, who shouldnt take certain prescription weight loss medications

A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss

This entire process depends on adequate gastric acid, proper enzyme secretion, and appropriate transit time through the GI tract