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10 Conclusions and clinical take-home messages 10.1 Main findings: certainties amidst uncertainties Synthesizing the current evidence, the information architecture regarding GLP-1RAs in PCOS fertility management exhibits a characteristic gradient: robust metabolic evidence, hypothesis-generating reproductive findings, and a gray zone of safety. Robust metabolic benefit: in overweight or obese PCOS phenotypes, evidence for the improvement of metabolic endpointsincluding body weight, central adiposity, and IRis consistently positive, facilitating the establishment of actionable therapeutic goals (e.g., reaching clinically significant weight-loss thresholds and optimizing IR markers)

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A phase II clinical trial involving patients who had received photodynamic therapy (PDT) found that melanotan 1 improved mood and outlook compared with the control group

10.3390/molecules15031196 Molecules 161 RodierF.CoppeJ

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