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The most clinically meaningful weight loss with retatrutide, as demonstrated in trial data, accumulates progressively over several months

That said, these trials used different populations and durations, so direct comparison has limits

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Rapid weight loss from semaglutide can affect estrogen levels, which may disrupt the hypothalamic-pituitary-ovarian (HPO) axis and lead to menstrual irregularities or breakthrough bleeding

Yes low fiber, dysbiosis, or inflammation reduces SCFAs, weakening GLP-1 output and increasing hunger and cravings