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Some users report experiencing anhedonia (a lack of pleasure in previously enjoyable activities), as their brain's normal pathways for reward and satisfaction are disrupted

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Chiang, C.-F., Lin, Y.-H., Fu, C.-C., Wang, N.-Y., Chen, Y.-A., Chang, C.-F., & Chan, S.-T

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Current Neuropharmacology, 23(8).

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However, this is harder to self-administer correctly, so we usually recommend sticking with the thigh or stomach

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