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Their primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , promoting satiety and reducing food intake Acting on appetite centres in the brain to decrease hunger signals Microdosing refers to the practice of using substantially lower doses of a medication than those typically prescribed for its licensed indications

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Patients should be counseled to start gradually and increase activity as tolerated

If those are positive, Lilly is plausibly looking at a 2028 FDA submission and a 2029 or 2030 launch