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This could explain why infection of mice with oral Trepomnema denticola bacteria induces Tau hyperphosphorylation and A accumulation in mice in the hippocampus with neuronal loss (Wu et al., 2022), and why filtrates of Helicobacter pylori bacteria induce Tau hyperphosphorylation in mouse neuroblastoma cells and rat brains via GSK-3 activation (Wang et al., 2014)

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Risk reduction strategies include maintaining stable weight before surgery, optimizing nutrition with adequate protein intake, avoiding nicotine products, and following post-operative instructions carefully