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Consider a supervised dechallenge (temporary discontinuation) only when clinically safe and when the riskbenefit balance becomes unfavourable, documenting symptom response

Pain Relief: Some studies suggest DSIP may have analgesic properties, providing relief from chronic pain

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Moreover, butyric acid and propionic acid produced by the gut microbiota can promote the differentiation of peripheral Tregs and maintain immune homeostasis (Kim et al., 2014