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ILC2 are a source of IL-13 and are the most recent cells proposed to regulate metabolic homeostasis in adipose tissue in both humans and mice (116118)
In addition, purinoreceptor subtype 7 activation has been observed to cause caspase-1 activation, which is ultimately involved in the expression of cyclooxygenase 2 and prostaglandin E2 and IL- production
This steroid hormone primarily originates from the ovarian corpus luteum, with smaller contributions from the adrenal glands and placental synthesis during pregnancy (138, 139)
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SLC25A19 transports ThPP 21 , the critical cofactor for the E1 subunit of the mitochondrial pyruvate dehydrogenase complex (PDC) and oxoglutarate dehydrogenase complex (OGDC) (Supplementary Fig
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