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What Does the Pharmacokinetic Picture Look Like

This provides a rationale for the effect of mutagenesis of R190 2.60 and K197 2.67 , which were two of the few TMD residues that had a large impact on exendin-P5 affinity (Supplementary Figs 5 and 9)

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30,58 These investigational therapies, as summarized in Table 3, reflect a shift toward mechanism-driven treatment in CLE, targeting underlying immune dysregulation to improve symptomatic control and patient outcomes