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Cell culture Human malignant melanoma (A375) cells were obtained from the American Type Culture Collection (ATCC, CRL-1619IG-2) and used within ten passages for all experiments

Endnotes and References The efficacy estimand with weight management represents efficacy in all randomized participants who remained on the study intervention (with possible dose modifications) without initiating prohibited weight management treatments

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Recent reports indicate improved supply for major branded formulations, though some regions and dosage strengths remain subject to periodic constraints, making informed alternative planning clinically prudent

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