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(2007) 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

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In this regard, our data showed a similar pharmacological profile on glucose-dependent insulinotropic polypeptide receptor (GIPR), with similar efficacy than with GLP-1R, indicating a dual agonist profile rather than strict GLP-1R selectivity, as shown in Figure 6