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The gut peptides signaling to the hypothalamus act via the ARC to mediate the appetite stimulation (+) effect through the activation of neurons containing neuropeptide Y (NPY) and Agouti-Related Peptide (AgRP) or appetite-inhibitory effects (-) via neurons containing the preopiomelanocortin (POMC)-derived alpha-melanocyte stimulating hormone (alpha-MSH) and cocaine and amphetamine regulated transcript (CART) peptide to hunger centers in the LHA, the satiety center in PVN in the medial hypothalamus (16)

There are some groups who may benefit from or need to supplement due to a B12 deficiency

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