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In the SUSTAIN-6 trial, semaglutide was associated with a significant increased risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or conditions requiring treatment with an intravitreal agent or photocoagulation (HR 1.76, 95% CI 1.112.78) [27]

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Practical tips for resuming treatment include: Set multiple reminders on your phone for injection days Keep your Wegovy pen in a visible location (whilst maintaining proper refrigeration) Use a medication tracking app to log each dose Inform your prescriber immediately if supply issues or side effects cause treatment gaps If you've missed multiple doses due to side effects, do not restart without medical review, as dose adjustment or alternative management strategies may be appropriate

Late complications include decreased bone mineral density, cardiomyopathy, vitamin and mineral deficiencies, impaired liver function, optic neuropathy, anemia, constipation, and increased atherosclerosis [206]