Semaglutides mechanism of action in aiding weight loss is a multifaceted process that involves various physiological pathways
PMID 20303587
Conversely, excessive lipid droplet accumulation within astrocytes and microglia is frequently associated with activation of pro-inflammatory transcriptional programs and release of neurotoxic mediators, thereby contributing to neuronal dysfunction and injury (Ralhan et al., 2021)
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[9] These effects are thought to arise partly through the indirect benefits of weight loss itself when body weight decreases, particularly visceral fat, the inflammatory burden carried by adipose tissue tends to reduce correspondingly