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The Russian framework emphasizes that benefits accrue over multiple cycles

10.1002/mnfr.202200784 [DOI] [PubMed] [Google Scholar] 138.Lohning A, Kidachi Y, Kamiie K, Sasaki K, Ryoyama K, Yamaguchi H

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Transfusion may improve oxygen delivery and dilute out the number of sickle cells, and thus is beneficial in certain conditions ( Currently, the only two curative treatments of SCD are hematopoietic stem cell transplantation (HSCT) and Lyfgenia, another recently FDA-approved gene therapy that modifies patients stem cells to produce normal hemoglobin (Figure 1)