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For the triaged subset of target-specific binders investigated in this study, those with native pairings showed improved in silico and in vitro developability relative to their randomly paired counterparts, particularly for metrics implicated in the molecules in vivo clearance 23,39
[DOI] [PubMed] [Google Scholar] Viguie CA, Frei B, Shigenaga MK, et al
While not ideal, it may not have ruined the entire vial
Decades of research have highlighted the clinical demerits of abnormally high body weight (BW), with BMIs exceeding 30 kg/m 2 and 40 kg/m 2 correlated with decreased life expectancies of three and 10 years, respectively
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