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Furthermore, the literature indicates that aside from their benefits in weight management and glycemic control, GLP-1 RAs have favorable effects on metabolic profiles, including blood pressure and lipid levels 22

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This oncometabolite impairs cytotoxic T-cells function while CRC cells preference for glycolysis over OXPHOS further reinforces immune evasion mechanisms, critically shaping therapeutic responses to immunotherapy

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He said the drug, which comes in an injectable pen, required a special manufacturing process that Apotex did not currently have